解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The freshwater snail Lymnaea stagnalis (L. stagnalis) has served as a successful model for studies in the field of Neuroscience. However, a serious drawback in the molecular analysis of the nervous system of L. stagnalis has been the lack of large-scale genomic or neuronal transcriptome information, thereby ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-451
更新日期:2009-09-23 00:00:00
abstract:BACKGROUND:Oceans cover more than 70% of the earth's surface and are critical for the homeostasis of the environment. Among the components of the ocean ecosystem, zooplankton play vital roles in energy and matter transfer through the system. Despite their importance, understanding of zooplankton biodiversity is limited...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-438
更新日期:2009-09-17 00:00:00
abstract:BACKGROUND:'Systems-wide' approaches such as microarray RNA-profiling are ideally suited to the study of the complex overlapping responses of plants to biotic and abiotic stresses. However, commercial microarrays are only available for a limited number of plant species and development costs are so substantial as to be ...
journal_title:BMC genomics
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2164-10-436
更新日期:2009-09-16 00:00:00
abstract:BACKGROUND:Proliferation and tumor differentiation captured by the genomic grade index (GGI) are important prognostic indicators in breast cancer (BC) especially for the estrogen receptor positive (ER+) disease. The aims of this study were to convert this microarray index to a qRT-PCR assay (PCR-GGI), which could be re...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-424
更新日期:2009-09-10 00:00:00
abstract:BACKGROUND:The ultimate phenome of any organism is modulated by regulated transcription of many genes. Characterization of genetic makeup is thus crucial for understanding the molecular basis of phenotypic diversity, evolution and response to intra- and extra-cellular stimuli. Chickpea is the world's third most importa...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-415
更新日期:2009-09-05 00:00:00
abstract:BACKGROUND:Mapping DNaseI hypersensitive sites is commonly used to identify regulatory regions in the genome. However, currently available methods are either time consuming and laborious, expensive or require large numbers of cells. We aimed to develop a quick and straightforward method for the analysis of DNaseI hyper...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-412
更新日期:2009-09-04 00:00:00
abstract:BACKGROUND:Despite its primary economic importance, genomic information on olive tree is still lacking. 454 pyrosequencing was used to enrich the very few sequence data currently available for the Olea europaea species and to identify genes involved in expression of fruit quality traits. RESULTS:Fruits of Coratina, a ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-399
更新日期:2009-08-26 00:00:00
abstract:BACKGROUND:Chronic renal disease (CKD) is characterized by complex changes in cell metabolism leading to an increased production of oxygen radicals, that, in turn has been suggested to play a key role in numerous clinical complications of this pathological condition. Several reports have focused on the identification o...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-388
更新日期:2009-08-21 00:00:00
abstract:BACKGROUND:Oral squamous cell carcinoma (OSCC) is one of the most common forms of cancer associated with the presence of precancerous oral leukoplakia. Given the poor prognosis associated with oral leukoplakia, and the difficulties in distinguishing it from cancer lesions, there is an urgent need to elucidate the molec...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-383
更新日期:2009-08-19 00:00:00
abstract:BACKGROUND:Detoxification in the liver involves activation of nuclear receptors, such as the constitutive androstane receptor (CAR), which regulate downstream genes of xenobiotic metabolism. Frequently, the metabolism of endobiotics is also modulated, resulting in potentially harmful effects. We therefore used 1,4-Bis ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-384
更新日期:2009-08-19 00:00:00
abstract:BACKGROUND:Allelic variation is the cornerstone of genetically determined differences in gene expression, gene product structure, physiology, and behavior. However, allelic variation, particularly cryptic (unknown or not annotated) variation, is problematic for follow up analyses. Polymorphisms result in a high inciden...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-379
更新日期:2009-08-17 00:00:00
abstract:BACKGROUND:Venomous animals incapacitate their prey using complex venoms that can contain hundreds of unique protein toxins. The realisation that many of these toxins may have pharmaceutical and insecticidal potential due to their remarkable potency and selectivity against target receptors has led to an explosion in th...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-375
更新日期:2009-08-13 00:00:00
abstract:BACKGROUND:Using a combination of pyrosequencing and conventional Sanger sequencing, the complete genome sequence of the recently described novel Brucella species, Brucella microti, was determined. B. microti is a member of the genus Brucella within the Alphaproteobacteria, which consists of medically important highly ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-352
更新日期:2009-08-04 00:00:00
abstract:BACKGROUND:Initial interest in Dechloromonas aromatica strain RCB arose from its ability to anaerobically degrade benzene. It is also able to reduce perchlorate and oxidize chlorobenzoate, toluene, and xylene, creating interest in using this organism for bioremediation. Little physiological data has been published for ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-351
更新日期:2009-08-03 00:00:00
abstract:BACKGROUND:Association mapping approaches are dependent upon discovery and validation of single nucleotide polymorphisms (SNPs). To further association studies in Anopheles gambiae we conducted a major resequencing programme, primarily targeting regions within or close to candidate genes for insecticide resistance. RE...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-320
更新日期:2009-07-16 00:00:00
abstract:BACKGROUND:NOD26-like intrinsic proteins (NIPs) that belong to the aquaporin superfamily are plant-specific and exhibit a similar three-dimensional structure. Experimental evidences however revealed that functional divergence should have extensively occurred among NIP genes. It is therefore intriguing to further invest...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-313
更新日期:2009-07-15 00:00:00
abstract::The Avian Genomics Conference and Gene Ontology Annotation Workshop brought together researchers and students from around the world to present their latest research addressing the delivery of value from the billions of base-pairs of Archosaur sequence that have become available in the last few years. This editorial de...
journal_title:BMC genomics
pub_type:
doi:10.1186/1471-2164-10-S2-I1
更新日期:2009-07-14 00:00:00
abstract:BACKGROUND:Crocodilians (Order Crocodylia) are an ancient vertebrate group of tremendous ecological, social, and evolutionary importance. They are the only extant reptilian members of Archosauria, a monophyletic group that also includes birds, dinosaurs, and pterosaurs. Consequently, crocodilian genomes represent a gat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-S2-S9
更新日期:2009-07-14 00:00:00
abstract:BACKGROUND:GLV-1h68 is an attenuated recombinant vaccinia virus (VACV) that selectively colonizes established human xenografts inducing their complete regression. RESULTS:Here, we explored xenograft/VACV/host interactions in vivo adopting organism-specific expression arrays and tumor cell/VACV in vitro comparing VACV ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-301
更新日期:2009-07-07 00:00:00
abstract:BACKGROUND:The steadily increasing number of prokaryotic genomes has accelerated the study of genome evolution; in particular, the availability of sets of genomes from closely related bacteria has facilitated the exploration of the mechanisms underlying genome plasticity. The family Vibrionaceae is found in the Gammapr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-S1-S11
更新日期:2009-07-07 00:00:00
abstract:INTRODUCTION:In the classification of Mass Spectrometry (MS) proteomics data, peak detection, feature selection, and learning classifiers are critical to classification accuracy. To better understand which methods are more accurate when classifying data, some publicly available peak detection algorithms for Matrix assi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-S1-S3
更新日期:2009-07-07 00:00:00
abstract:BACKGROUND:Sand fly saliva plays an important role in blood feeding and Leishmania transmission as it was shown to increase parasite virulence. On the other hand, immunity to salivary components impedes the establishment of infection. Therefore, it is most desirable to gain a deeper insight into the composition of sali...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-282
更新日期:2009-06-25 00:00:00
abstract:BACKGROUND:Meta-analysis of QTLs combines the results of several QTL detection studies and provides narrow confidence intervals for meta-QTLs, permitting easier positional candidate gene identification. It is usually applied to multiple mapping populations, but can be applied to one. Here, a meta-analysis of drought re...
journal_title:BMC genomics
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2164-10-276
更新日期:2009-06-22 00:00:00
abstract:BACKGROUND:Transcriptome expression analysis in peanut to date has been limited to a relatively small set of genes and only recently has a significant number of ESTs been released into the public domain. Utilization of these ESTs for oligonucleotide microarrays provides a means to investigate large-scale transcript res...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-265
更新日期:2009-06-12 00:00:00
abstract:BACKGROUND:Homology-based comparisons of the genes involved in innate immunity across many insect taxa with fully sequenced genomes has revealed a striking pattern of gene gain and loss, particularly among genes that encode proteins involved in clearing pathogens (effectors). However, limited functional annotation in n...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-259
更新日期:2009-06-07 00:00:00
abstract:BACKGROUND:The mosquito Anopheles gambiae is a major vector of human malaria. Increasing evidence indicates that blood cells (hemocytes) comprise an essential arm of the mosquito innate immune response against both bacteria and malaria parasites. To further characterize the role of hemocytes in mosquito immunity, we un...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-257
更新日期:2009-06-05 00:00:00
abstract:BACKGROUND:Pharmacological and gene ablation studies have demonstrated the crucial role of the endocrine function of the heart as mediated by the polypeptide hormones ANF and BNP in the maintenance of cardiovascular homeostasis. The importance of these studies lies on the fact that hypertension and chronic congestive h...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-254
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:The human zinc finger protein 191 (ZNF191) is a member of the SCAN domain family of Krüppel-like zinc finger transcription factors. ZNF191 shows 94% identity to its mouse homologue zinc finger protein 191(Zfp191), which is the most highly conserved among the human-mouse SCAN family member orthologues pairs. ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-241
更新日期:2009-05-22 00:00:00
abstract:BACKGROUND:Electron microscopy analyses of replicating chloroplast molecules earlier predicted bidirectional Cairns replication as the prevalent mechanism, perhaps followed by rounds of a rolling circle mechanism. This standard model is being challenged by the recent proposition of homologous recombination-mediated rep...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-237
更新日期:2009-05-20 00:00:00
abstract:BACKGROUND:The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventional versus innate-like T-cell development. We have characterized the transcriptome of Itk-deficient CD3+ T-cells, including CD4+ and CD8+ subsets, using Affymetrix microarrays. RESULTS:The lar...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-233
更新日期:2009-05-18 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs affecting the expression of target genes via translational repression or mRNA degradation mechanisms. With the increasing availability of mRNA and miRNA expression data, it might be possible to assess functional targets using the fact that a miRNA might down-regul...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-218
更新日期:2009-05-12 00:00:00
abstract:BACKGROUND:The recently developed RNA interference (RNAi) technology has created an unprecedented opportunity which allows the function of individual genes in whole organisms or cell lines to be interrogated at genome-wide scale. However, multiple issues, such as off-target effects or low efficacies in knocking down ce...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-220
更新日期:2009-05-12 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs), short approximately 21-nucleotide RNA molecules, play an important role in post-transcriptional regulation of gene expression. The number of known miRNA hairpins registered in the miRBase database is rapidly increasing, but recent reports suggest that many miRNAs with restricted temporal ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-204
更新日期:2009-04-30 00:00:00
abstract:BACKGROUND:We have reported that doxycycline-induced over-expression of wild type prion protein (PrP) in skeletal muscles of Tg(HQK) mice is sufficient to cause a primary myopathy with no signs of peripheral neuropathy. The preferential accumulation of the truncated PrP C1 fragment was closely correlated with these myo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-201
更新日期:2009-04-28 00:00:00
abstract:BACKGROUND:We present here the assembly of the bovine genome. The assembly method combines the BAC plus WGS local assembly used for the rat and sea urchin with the whole genome shotgun (WGS) only assembly used for many other animal genomes including the rhesus macaque. RESULTS:The assembly process consisted of multipl...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-180
更新日期:2009-04-24 00:00:00
abstract:BACKGROUND:The Pregnancy-associated glycoproteins (PAGs) belong to a large family of aspartic peptidases expressed exclusively in the placenta of species in the Artiodactyla order. In cattle, the PAG gene family is comprised of at least 22 transcribed genes, as well as some variants. Phylogenetic analyses have shown th...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-185
更新日期:2009-04-24 00:00:00
abstract::The draft genome sequence of cattle (Bos taurus) has now been analyzed by the Bovine Genome Sequencing and Analysis Consortium and the Bovine HapMap Consortium, which together represent an extensive collaboration involving more than 300 scientists from 25 different countries. ...
journal_title:BMC genomics
pub_type: 社论
doi:10.1186/1471-2164-10-193
更新日期:2009-04-24 00:00:00
abstract:BACKGROUND:Cytochrome P450s (CYPs) in animals fall into two categories: those that synthesize or metabolize endogenous molecules and those that interact with exogenous chemicals from the diet or the environment. The latter form a critical component of detoxification systems. RESULTS:Data mining and manual curation of ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-169
更新日期:2009-04-21 00:00:00
abstract:BACKGROUND:Modifications of RNA bases have been found in some mRNAs and non-coding RNAs including rRNAs, tRNAs, and snRNAs, where modified bases are important for RNA function. Little is known about RNA base modifications in Arabidopsis thaliana. RESULTS:In the current work, we carried out a bioinformatics analysis of...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-155
更新日期:2009-04-09 00:00:00
abstract:BACKGROUND:The pituitary is a critical neuroendocrine gland that is comprised of five hormone-secreting cell types, which develops in tandem during the embryonic stage. Some essential genes have been identified in the early stage of adenohypophysial development, such as PITX1, FGF8, BMP4 and SF-1. However, it is likely...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-109
更新日期:2009-03-15 00:00:00